British Air Force Typhoon FGR4s have operated alongside French warplanes in a coordinated attack targeting an subterranean weapons facility in Syrian territory used by the IS group, according to the UK Ministry of Defence.
The location, located using reconnaissance, was assessed as containing munitions and bombs, the release indicated, and was situated in mountains just to the north of Palmyra in the heart of Syria.
"Our aircraft employed Paveway IV guided bombs to target a series of access tunnels leading to the site... early reports are that the strike was effective," the ministry announced.
There was no indication of any civilian impact in the operation on Saturday evening and every plane involved returned to base without incident, the MoD added.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as Daesh - enforced militant control over significant areas in Iraq and Syria prior to its 2019 collapse.
"This action demonstrates British leadership, and determination to operate in unison with our allies, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the region," Britain's Defence Chief the Defence Secretary said.
RAF aircraft have conducted surveillance missions over Syria to "deter any efforts to regroup" of Islamic State following its routing at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of our armed forces involved in this mission for their expertise and their valour," he added. "Including them were thousands of UK service members on duty over the holidays. This mission, to take out terrorist threats who pose a risk to our safety, demonstrates how British military are always on standby, throughout the year, protecting the UK within its borders and influential overseas."
In December, the United States armed forces conducted what it termed a "massive strike" on IS targets in Syria, after an ambush resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The U.N. reports Islamic State still boasts roughly 5-7 thousand combatants in Syria and Iraq.